Transient Oxidative Stress Damages Mitochondrial Machinery Inducing Persistent β-Cell Dysfunction
نویسندگان
چکیده
منابع مشابه
Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.
Transient exposure of beta-cells to oxidative stress interrupts the transduction of signals normally coupling glucose metabolism to insulin secretion. We investigated putative persistence of effects induced by one transient oxidative stress (200 microm H(2)O(2), 10 min) on insulin secreting cells following recovery periods of days and weeks. Three days after oxidative stress INS-1E cells and ra...
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1 Laboratory of Bioenergetics, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil 2 Department of Cellular Signaling, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland 3Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, M...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.m109.024323